PD 118,576: a new antitumor macrolide antibiotic.

Synthetic study on an antitumor antibiotic rhizoxin by using an enzymatic process on prochiral @ - substituted glutarates

rhizoxin was achieved by enzymatic approach. Characteristic features of the present synthesis are (1) enantioselective hydrolysis of prochiral P-substituted glutarates with pig liver estemse, and (2) stereoselective cyclichydroboration of the 1,5-diene 8. Enantioand stereoselective synthesis of the right-half segment (1, Cl-Cg) of macrolide antibiotic Rhizoxin is an antitumor antibiotic isolate...

PD 116,779, a new antitumor antibiotic of the benz[a]anthraquinone class.

Effects of Vitamin K3 on Cytotoxicity and DNA-binding Properties of a Palladium(II) Complex as a Potential Antitumor Agent

In many diseases such as cancer, simultaneous use of two or more pharmacologically active agents will be more effective and have fewer side effects. In this study a new palladium(II) complex with formula of [Pd(phen)(py-dtc)]NO3 (where is phen 1,10-phenanthroline and py-dtc is n-propyldithiocarbamate), was synthesized. The cytotoxic activity of this complex was tested against leukemia K562 cell...

PD 116,152, a new phenazine antitumor antibiotic. Structure and antitumor activity.

A new, highly substituted phenazine with antitumor activity was isolated from the culture broth of a Streptomyces sp. This compound, whose structure was determined by spectroscopic methods and verified by X-ray diffraction analysis, was found to be methyl 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylate.

Antimicrobial susceptibility and analysis of macrolide resistance genes in Streptococcus pneumoniae isolated in Hamadan

Objective(s): Macrolide resistant Streptococcus pneumoniae pose an emerging problem globally. The aim of this study was to investigate the prevalence of ermB and mefA genes (macrolide resistant genes) by polymerase chain reaction (PCR) method and to detect drug resistance patterns of S. pneumoniae isolated from clinical samples to macrolides and other antibiotic agents by E-test method. Materia...